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This supplement issue of 'Oncology Research and Treatment' contains
contributions discussing the subject in-depth. 'Oncology Research
and Treatment' is a well-respected, international peer-reviewed
journal in oncology. Supplement issues are included in the
subscription.
The discovery of uniform latex particles by polymer chemists of the
Dow Chemical Company nearly 50 years ago opened up new exciting
fields for scientists and physicians and established many new
biomedical applications. Many in vitro diagnostic tests such as the
latex agglutination tests, analytical cell and phagocytosis tests
have since become rou tine. They were all developed on the basis of
small particles bound to biological active molecules and
fluorescent and radioactive markers. Further developments are
ongoing, with the focus now shifted to applications of polymer
particles in the controlled and di rected transport of drugs in
living systems. Four important factors make microspheres
interesting for in vivo applications: First, biocompatible polymer
particles can be used to transport known amounts of drug and re
lease them in a controlled fashion. Second, particles can be made
of materials which bio degrade in living organisms without doing
any harm. Third, particles with modified surfaces are able to avoid
rapid capture by the reticuloendothelial system and therefore en
hance their blood circulation time. Fourth, combining particles
with specific molecules may allow organ-directed targeting."
These hilarious sketches are uncannily true reflections of the
Greater European State we now live in. From his base in Geneva, the
author observes the follies of French estate agents, Swiss choirs,
Italian driving instructors, UN 'workers', musical CVs, operatic
subtitles and the great IT debate. He also has time to note the
oxymoron implicit in 'Swiss bag ladies' and the paradoxes in
Shakespeare's dialogue. In sum, these are quick-witted,
light-hearted sideswipes at our so-called 'culture' and our
dependence on information technology. Heed the call and enjoy them
all!
The discovery of uniform latex particles by polymer chemists of the
Dow Chemical Company nearly 50 years ago opened up new exciting
fields for scientists and physicians and established many new
biomedical applications. Many in vitro diagnostic tests such as the
latex agglutination tests, analytical cell and phagocytosis tests
have since become rou tine. They were all developed on the basis of
small particles bound to biological active molecules and
fluorescent and radioactive markers. Further developments are
ongoing, with the focus now shifted to applications of polymer
particles in the controlled and di rected transport of drugs in
living systems. Four important factors make microspheres
interesting for in vivo applications: First, biocompatible polymer
particles can be used to transport known amounts of drug and re
lease them in a controlled fashion. Second, particles can be made
of materials which bio degrade in living organisms without doing
any harm. Third, particles with modified surfaces are able to avoid
rapid capture by the reticuloendothelial system and therefore en
hance their blood circulation time. Fourth, combining particles
with specific molecules may allow organ-directed targeting."
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